Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and by inhibiting the reuptake of monoamines in the CNS. However, the precise mode of modulation remains unclear. We used an in vivo patch clamp technique in urethane-anesthetized rats to determine the antinociceptive mechanism of tra-madol. In vivo whole-cell recordings of spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) were made from substantia gelatinosa (SG) neurons (lamina II) at holding potentials of 0 mV and-70 mV, re-spectively. The effects of intravenous administration (0.5, 5, 15 mg/kg) of tramadol were evaluated. The effects of superfusion of trama...
Objective: Tramadol hydrochloride is a centrally acting analgesic drug, used mainly as an analgesic ...
Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This ...
<p>(A) Systemic tramadol (5 mg/kg) increased sIPSCs. (B) Cumulative probability plots obtained from ...
<p>Graph A shows a dose-dependent effect of intrathecal tramadol on SNL-induced mechanical allodynia...
Background: Tramadol is an opioid analgesic used for treating moderate to severe pain. No research i...
WOS: 000250099200002PubMed ID: 17651791The aim of the present study was to investigate the possible ...
<p>Superfusion of tramadol at clinically relevant concentration (10 μM) onto the surface of the spin...
WOS: 000290353100004Objective: Tramadol hydrochloride is a centrally acting analgesic drug, used mai...
International audienceTramadol is one of the most commonly prescribed analgesic opioids in various p...
<p>(A) Systemic tramadol (5 mg/kg) inhibited sEPSCs. (B) Cumulative probability plots obtained from ...
Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful fo...
1. Tramadol hydrochloride is a centrally acting opioid analgesic, the efficacy and potency of which ...
PubMedID: 17196585Several studies have suggested that systemic tramadol, an opioid, can represent a ...
Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been repo...
Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been repo...
Objective: Tramadol hydrochloride is a centrally acting analgesic drug, used mainly as an analgesic ...
Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This ...
<p>(A) Systemic tramadol (5 mg/kg) increased sIPSCs. (B) Cumulative probability plots obtained from ...
<p>Graph A shows a dose-dependent effect of intrathecal tramadol on SNL-induced mechanical allodynia...
Background: Tramadol is an opioid analgesic used for treating moderate to severe pain. No research i...
WOS: 000250099200002PubMed ID: 17651791The aim of the present study was to investigate the possible ...
<p>Superfusion of tramadol at clinically relevant concentration (10 μM) onto the surface of the spin...
WOS: 000290353100004Objective: Tramadol hydrochloride is a centrally acting analgesic drug, used mai...
International audienceTramadol is one of the most commonly prescribed analgesic opioids in various p...
<p>(A) Systemic tramadol (5 mg/kg) inhibited sEPSCs. (B) Cumulative probability plots obtained from ...
Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful fo...
1. Tramadol hydrochloride is a centrally acting opioid analgesic, the efficacy and potency of which ...
PubMedID: 17196585Several studies have suggested that systemic tramadol, an opioid, can represent a ...
Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been repo...
Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been repo...
Objective: Tramadol hydrochloride is a centrally acting analgesic drug, used mainly as an analgesic ...
Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This ...
<p>(A) Systemic tramadol (5 mg/kg) increased sIPSCs. (B) Cumulative probability plots obtained from ...