Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this genomic instability are still poorly understood. Because the Fanconi anemia (FA) pathway is believed to control several mechanisms of DNA repair, we investigated whether this pathway was disrupted in CML cells. Our data show that CML cells have a defective capacity to generate FANCD2 nuclear foci, either in dividing cells or after DNA damage. Similarly, human cord blood CD34+ cells transduced with BCR/ABL retroviral vectors showed impaired FANCD2 foci formation, whereas FANCD2 monoubiquitination ...
The most recent two decades have seen tremendous progress in the understanding and treatment of chro...
AbstractChronic myelogeneous leukemia (CML) is a two-stage disease associated with expression of the...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracell...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
This work was supported by grants from the European Program "Life Sciences, Genomics and Biotechnolo...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks...
Chronic myeloid leukemia (CML) is a two-stage disease caused by the p210 BCR-ABL protein. BCR-ABL is...
Genomic instability is a common feature of cancer cells, which can result from aberrant DNA damage r...
The BCR/ABL chimeric protein plays a central role in the pathogenesis of chronic myelogenous leukemi...
Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL oncogene, located on the Phi...
The Bcr-abl translocation arises from a reciprocal translocation between chromosomes 9 and 22 and re...
Chronic myeloid leukemia (CML) is a two-stage disease caused by the p210 BCR-ABL protein. BCR-ABL is...
Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell producti...
The most recent two decades have seen tremendous progress in the understanding and treatment of chro...
AbstractChronic myelogeneous leukemia (CML) is a two-stage disease associated with expression of the...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracell...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
This work was supported by grants from the European Program "Life Sciences, Genomics and Biotechnolo...
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by ...
Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks...
Chronic myeloid leukemia (CML) is a two-stage disease caused by the p210 BCR-ABL protein. BCR-ABL is...
Genomic instability is a common feature of cancer cells, which can result from aberrant DNA damage r...
The BCR/ABL chimeric protein plays a central role in the pathogenesis of chronic myelogenous leukemi...
Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL oncogene, located on the Phi...
The Bcr-abl translocation arises from a reciprocal translocation between chromosomes 9 and 22 and re...
Chronic myeloid leukemia (CML) is a two-stage disease caused by the p210 BCR-ABL protein. BCR-ABL is...
Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell producti...
The most recent two decades have seen tremendous progress in the understanding and treatment of chro...
AbstractChronic myelogeneous leukemia (CML) is a two-stage disease associated with expression of the...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracell...