Pipoxolan (PIPO) has anti-spasmodic effects, and it is used clinically to relieve smooth muscle spasms. Cerebrovascular disease is one of the leading causes of disability and death worldwide. The main aim of this study was to investigate the effects of PIPO on cerebral ischemia and vascular smooth muscle cell (VSMC) migration in vivo and in vitro. Cerebral infarction area, ratio of intima to media area (I/M ratio) and PCNA antibody staining of the carotid artery in vivo were measured. Cell viability of A7r5 cells, PDGF-BB-stimulated cell migration, and potential mechanisms of PIPO were evaluated by wound healing, transwell and Western blotting. PIPO (10 and 30 mg/kg p.o.) reduced: the cerebral infarction area; neurological deficit; TUNEL-po...
Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. ...
Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been ...
<div><p>This paper aimed to explore the protective effects of picroside II against the neuronal apop...
<p>(A) Effects of PIPO (10, 30 mg/kg p.o.) groups on cerebral infarct area at 24 hr after reperfusio...
[[abstract]]Restenosis is resulted from the proliferation and migration of vascular smooth muscle ce...
BACKGROUND AND PURPOSE:Thrombolysis is used to improve cerebral circulation; at the same time, neuro...
PURPOSE: Vascular smooth muscle cells (VSMCs) migration and proliferation play important roles in tr...
AIM: To explore the effect of simvastatin on proliferation of vascular smooth muscle cells (VSMCs) d...
Abstract—Vascular smooth muscle cell (SMC) migration and proliferation contribute to neointimal hype...
This paper aimed to explore the protective effects of picroside II against the neuronal apo-ptosis a...
Objective: Panax notoginseng saponins (PNS), extracted from rhizome of the herb Radix et Rhizoma Not...
Aims: The purpose of the research presented in this thesis is to elucidate the mechanis...
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)...
Purpose. In this report, we investigated the protective mechanism of scutellarin (SCU) in vitro and ...
Abstract Background Panaxatrio...
Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. ...
Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been ...
<div><p>This paper aimed to explore the protective effects of picroside II against the neuronal apop...
<p>(A) Effects of PIPO (10, 30 mg/kg p.o.) groups on cerebral infarct area at 24 hr after reperfusio...
[[abstract]]Restenosis is resulted from the proliferation and migration of vascular smooth muscle ce...
BACKGROUND AND PURPOSE:Thrombolysis is used to improve cerebral circulation; at the same time, neuro...
PURPOSE: Vascular smooth muscle cells (VSMCs) migration and proliferation play important roles in tr...
AIM: To explore the effect of simvastatin on proliferation of vascular smooth muscle cells (VSMCs) d...
Abstract—Vascular smooth muscle cell (SMC) migration and proliferation contribute to neointimal hype...
This paper aimed to explore the protective effects of picroside II against the neuronal apo-ptosis a...
Objective: Panax notoginseng saponins (PNS), extracted from rhizome of the herb Radix et Rhizoma Not...
Aims: The purpose of the research presented in this thesis is to elucidate the mechanis...
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)...
Purpose. In this report, we investigated the protective mechanism of scutellarin (SCU) in vitro and ...
Abstract Background Panaxatrio...
Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. ...
Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been ...
<div><p>This paper aimed to explore the protective effects of picroside II against the neuronal apop...