Add to ORKGAbstract Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans
<div><p>The battle for iron between invading microorganisms and mammalian hosts is a pivotal determi...
AbstractEukaryotic cells contain dozens, perhaps hundreds, of iron-dependent proteins, which perform...
AbstractIron–sulfur (Fe/S) clusters are important cofactors of numerous proteins involved in electro...
Iron–sulphur clusters (ISCs) are protein co-factors essential for a wide range of cellular functions...
In the yeast Saccharomyces cerevisiae, the transcription factor Aft1P regulates the expression of nu...
ABSTRACT Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet C...
The opportunistic pathogen Cryptococcus neoformans causes fungal meningoencephalitis in immunocompro...
MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitoc...
AbstractIron bioavailability is crucial for mitochondrial metabolism and biosynthesis. Dysregulation...
International audiencePlants have evolutionarily conserved NifU (NFU)-domain proteins that are targe...
Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzyme...
Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzyme...
ABSTRACT Mitochondria are essential organelles that act in pathways including ATP production, β-oxid...
ABSTRACT MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into ...
Cryptococcus neoformans is an opportunistic fungal pathogen with worldwide distribution. Pathogenes...
<div><p>The battle for iron between invading microorganisms and mammalian hosts is a pivotal determi...
AbstractEukaryotic cells contain dozens, perhaps hundreds, of iron-dependent proteins, which perform...
AbstractIron–sulfur (Fe/S) clusters are important cofactors of numerous proteins involved in electro...
Iron–sulphur clusters (ISCs) are protein co-factors essential for a wide range of cellular functions...
In the yeast Saccharomyces cerevisiae, the transcription factor Aft1P regulates the expression of nu...
ABSTRACT Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet C...
The opportunistic pathogen Cryptococcus neoformans causes fungal meningoencephalitis in immunocompro...
MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitoc...
AbstractIron bioavailability is crucial for mitochondrial metabolism and biosynthesis. Dysregulation...
International audiencePlants have evolutionarily conserved NifU (NFU)-domain proteins that are targe...
Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzyme...
Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzyme...
ABSTRACT Mitochondria are essential organelles that act in pathways including ATP production, β-oxid...
ABSTRACT MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into ...
Cryptococcus neoformans is an opportunistic fungal pathogen with worldwide distribution. Pathogenes...
<div><p>The battle for iron between invading microorganisms and mammalian hosts is a pivotal determi...
AbstractEukaryotic cells contain dozens, perhaps hundreds, of iron-dependent proteins, which perform...
AbstractIron–sulfur (Fe/S) clusters are important cofactors of numerous proteins involved in electro...