Research Article Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model Yen-Jing Zeng,1 Shih-Ying Tsai,2 Kuen-Bao Chen,2,3 Sheng-Feng Hsu,4,5,6

Copyright © 2014 Yen-Jing Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Electroacupuncture (EA) is a complementary therapy to improve morphine analgesia for postoperative pain, but underlying mechanism is notwell-known.Herein, we investigated EA-induced analgesic effect in a plantar incision (PI)model inmale Sprague-Dawley rats. PI was performed at the left hind paw. EA of 4Hz and high intensity or sham needling was conducted at right ST36 prior to PI and repeated for another 2 days. Behavioral responses to mechanical and thermal stimuli, spinal phospho-ERK, and Fos expression were all analyzed. In additional groups, naloxone and morphine were administered to elucidate involvement o