Acute zonal occult outer retinopathy (AZOOR)

was first described by J. Donald M. Gass in 1992[1] as a “syndrome ” characterized by sudden onset photopsia and acute scotomas related to loss of sectors of outer retinal function in typically young, otherwise healthy individuals including 10 female and 3 male subjects.[1] Early funduscopic appearance was often normal; however, most patients developed zones of retinal pigment epithelial (RPE) atrophy or pigment clumping in one or both eyes when followed over time.[2] Persistent visual field defects, some corresponding electroretinogram (ERG) changes, retinal arterial narrowing and eventually chorioretinal atrophy were usually observed.[1,2] The pathogenesis of the disease was uncertain, but Gass stated that a virus was the best explanation for the progressive abnormalitie