RESEARCH ARTICLE Effects of comprehensive li n

Full list of author information is available at the end of the articleHepatitis B virus (HBV) infection is a significant global health problem. An estimated two billion people world-wide have been infected with the hepatitis B virus and more than 240 million have chronic liver infections. About 600000 people die every year due to the acute or chronic consequences of hepatitis B [1]. The prevalence in China is high and includes an estimated 120 million with HBV, with a prevalence as high as 7.9 % [2,3]. Chronic hepatitis B (CHB) increased the risk of liver fail-ure and hepatocellular carcinoma. It imposes consider-able economic burden on a family [4]. The incidence rate of hepatitis B ranks first, and the mortality rate ranks third, among all infectious diseases. In 2005, viral hepatitis, AIDS, tuberculosis, and schistosomiasis were listed as the four most important infectious diseases for prevention and control in China [5]. For successful dis-ease control, comprehensive intervention is essential. I