RESEARCH ARTICLE Predicted protein-protein e

a b al lished experiments, several high-throughput methods have to as Arabidopsis), rice, coffee, yeast, human, mouse, and Schuette et al. BMC Bioinformatics (2015) 16:89 DOI 10.1186/s12859-015-0524-1requirement of high-throughput methods, which currently have only been done for selected model organisms. This USA Full list of author information is available at the end of the articlebeen developed to rapidly identify interactions between proteins even those with no known function. In doing so, high-throughput methods reveal much of the signalling and communication within the proteomes of yeast, human, fruit fly, and nematode worm [2-5]. With 84 % of the pro-teins interactions experimentally determined, the yeast fruit fly at the organelle and whole cell levels using com-putational interolog methodology [6,7,9-13]. The interolog method of predicting protein interactions is based on the hypothesis that conserved orthologous genes encode functionally similar proteins forming similar complexes and signalling pathways [1,14]. This method assumes that functionally similar proteins retain their interacting partners. Using interologs, a predicted protein interactome can be constructed without the extreme expense or time * Correspondence