ABSTRACT: Y-Family DNA polymerases specialize in translesion syn-thesis, bypassing damaged bases that would otherwise block the normal progression of replication forks. Y-Family polymerases have unique structural features that allow them to bind damaged DNA and use a modified template base to direct nucleotide incorporation. Each Y-Family polymerase is unique and has different preferences for lesions to bypass and for dNTPs to incorporate. Y-Family polymerases are also characterized by a low catalytic efficiency, a low processivity, and a low fidelity on normal DNA. Recruitment of these specialized polymerases to replication forks is therefore regulated. The catalytic center of the Y-Family polymerases is highly conserved and homologous to ...
Specialized DNA damage-bypass Y-family DNA polymerases contribute to cancer prevention by providing ...
AbstractModification of DNA is a common event, due to reaction with both exogenous and endogenous fa...
Dpo4 and Dbh are Y-family polymerases that originate from two closely related strains of Sulfolobace...
AbstractMembers of the Y-family of DNA polymerases catalyze template-dependent DNA synthesis but sha...
The integrity of DNA is essential for the survival of all living organisms. However, cellular DNA i...
DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DN...
The past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and...
DNA is a chemically reactive molecule that is subject to many different covalent modifications from ...
AbstractSulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs to the re...
) with a C. Human DNA polymerase κ (Polκ) is a member of the newly discovered Y-family of DNA polyme...
ABSTRACT: Numerous kinetic, structural, and theoretical studies have established that DNA polymerase...
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the repla...
Human DNA polymerase iota (pol iota) is a unique member of Y-family polymerases, which preferentiall...
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the repla...
Y family DNA polymerases are specialized enzymes for replication through sites of DNA damage in the ...
Specialized DNA damage-bypass Y-family DNA polymerases contribute to cancer prevention by providing ...
AbstractModification of DNA is a common event, due to reaction with both exogenous and endogenous fa...
Dpo4 and Dbh are Y-family polymerases that originate from two closely related strains of Sulfolobace...
AbstractMembers of the Y-family of DNA polymerases catalyze template-dependent DNA synthesis but sha...
The integrity of DNA is essential for the survival of all living organisms. However, cellular DNA i...
DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DN...
The past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and...
DNA is a chemically reactive molecule that is subject to many different covalent modifications from ...
AbstractSulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs to the re...
) with a C. Human DNA polymerase κ (Polκ) is a member of the newly discovered Y-family of DNA polyme...
ABSTRACT: Numerous kinetic, structural, and theoretical studies have established that DNA polymerase...
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the repla...
Human DNA polymerase iota (pol iota) is a unique member of Y-family polymerases, which preferentiall...
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the repla...
Y family DNA polymerases are specialized enzymes for replication through sites of DNA damage in the ...
Specialized DNA damage-bypass Y-family DNA polymerases contribute to cancer prevention by providing ...
AbstractModification of DNA is a common event, due to reaction with both exogenous and endogenous fa...
Dpo4 and Dbh are Y-family polymerases that originate from two closely related strains of Sulfolobace...