Add to ORKGPhase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pathogenic bacteria. Phase variably expressed N6-adenine DNA methyltransferases (Mod) alter global methylation patterns resulting in changes in gene expression. These systems constitute phase vari-able regulons called phasevarions. Neisseria menin-gitidis phasevarions regulate genes including viru-lence factors and vaccine candidates, and alter phe-notypes including antibiotic resistance. The target site recognized by these Type III N6-adenine DNA methyltransferases is not known. Single molecule, real-time (SMRT) methylome analysis was used to identify the recognition site for three key N. menin-gitidis methyltransferases: ModA11 (exemplified by...
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To presen...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...
Phase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pat...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Phase variation is a common feature of host-adapted bacterial pathogens such asNeisseria meningitidi...
Previous work carried out in our laboratory has identified that phase variation of type III R-M syst...
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To presen...
Phase variation, the high frequency reversible switching of gene expression, is a common feature of ...
<div><p>The Gram-negative bacterium <i>Neisseria meningitidis</i> features extensive genetic variabi...
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To presen...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...
Phase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pat...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningoc...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to...
Phase variation is a common feature of host-adapted bacterial pathogens such asNeisseria meningitidi...
Previous work carried out in our laboratory has identified that phase variation of type III R-M syst...
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To presen...
Phase variation, the high frequency reversible switching of gene expression, is a common feature of ...
<div><p>The Gram-negative bacterium <i>Neisseria meningitidis</i> features extensive genetic variabi...
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To presen...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic ...