Add to ORKGABSTRACT: A peptide derived from Aβ17−36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted β-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer’s disease. Here we report the X-ray crystallographic structures oftrimers and higher-order oligomeric assemblies of a peptide derived from the β-amyloid peptide (Aβ). Oligomers of Aβ are now thought to play a central role in neurodegeneration in Alzheimer’s dis...
Amyloid diseases such as Alzheimer’s disease, Parkinson’s disease, and type II diabetes share common...
Soluble oligomers of amyloid-β (Aβ) have been implicated as the culprit for neurodegeneration in Alz...
ConspectusIn the more than a century since its identification, Alzheimer’s disease has become the ar...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to understand ...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our unders...
The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our unders...
Amyloid oligomers play a central role in Alzheimer's and other amyloid diseases, and yet the structu...
Amyloid diseases such as Alzheimer’s disease, Parkinson’s disease, and type II diabetes share common...
Soluble oligomers of amyloid-β (Aβ) have been implicated as the culprit for neurodegeneration in Alz...
ConspectusIn the more than a century since its identification, Alzheimer’s disease has become the ar...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
A peptide derived from Aβ<sub>17–36</sub> crystallizes to form trimers that further associate to for...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in...
High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to understand ...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
Amyloid oligomers play a central role in Alzheimer’s and other amyloid diseases, and yet the structu...
The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our unders...
The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our unders...
Amyloid oligomers play a central role in Alzheimer's and other amyloid diseases, and yet the structu...
Amyloid diseases such as Alzheimer’s disease, Parkinson’s disease, and type II diabetes share common...
Soluble oligomers of amyloid-β (Aβ) have been implicated as the culprit for neurodegeneration in Alz...
ConspectusIn the more than a century since its identification, Alzheimer’s disease has become the ar...