Copyright © 2012 Micaela Morelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: induction, which is responsible for dyskinesia onset, and expression, which underlies its clinical manifestation. The unique cellular and regional distribution of adenosine A2A receptors in basal ganglia areas that are richly innervated by dopamine, and their antagonistic role towards dopamine receptor stimulation, have positioned A2A receptor antagonists as an attractive nondopaminergic target t...
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia, being...
Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the physiological functions...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Dyskinesia, a major complication of treatment of Parkinson's disease (PD), involves two phases: indu...
The motor symptoms of Parkinson’s disease (PD) are due primarily to the degeneration of the dopamine...
Adenosine is an endogenous purine nucleoside that regulates several physiological functions, at the ...
The drug treatment of Parkinson’s disease (PD) is accompanied by a loss of drug efficacy, the onset ...
The most effective treatment of Parkinson's disease (PD) is, at present, the dopamine precursor L-3,...
The development of non-dopaminergic therapies for the treatment of Parkinson's disease (PD) has attr...
Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia (BG)be...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Animal models of motor dysfunction constitute the basis for the screening of new drugs with potentia...
Adenosine A(2A) receptors present in the central nervous system have been implicated in the modulati...
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia, being...
Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the physiological functions...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Dyskinesia, a major complication of treatment of Parkinson's disease (PD), involves two phases: indu...
The motor symptoms of Parkinson’s disease (PD) are due primarily to the degeneration of the dopamine...
Adenosine is an endogenous purine nucleoside that regulates several physiological functions, at the ...
The drug treatment of Parkinson’s disease (PD) is accompanied by a loss of drug efficacy, the onset ...
The most effective treatment of Parkinson's disease (PD) is, at present, the dopamine precursor L-3,...
The development of non-dopaminergic therapies for the treatment of Parkinson's disease (PD) has attr...
Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia (BG)be...
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: indu...
Animal models of motor dysfunction constitute the basis for the screening of new drugs with potentia...
Adenosine A(2A) receptors present in the central nervous system have been implicated in the modulati...
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia, being...
Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the physiological functions...