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Hydroxyurea, which is an inhibitor of ribonucleosidereductase and is used as a systemic antitumor agent, is frequently used for the treatment of myeloproliferative and hematologic diseases. While the most common side effect is myelosuppression, gastrointestinal symptoms such as nausea, vomiting, stomatitis, and anorexia and rash, skin ulcers, hyperpigmentation in nails, and dermatologic toxicities like facial erythema may also be observed. At higher dosages, neurologic symptoms may be rarely seen (1,2). A 76-year-old female patient applied to the hematology polyclinic in August 2010 complaining about weakness. She had no other diseases except for hypertension. She had used acetylsalicylic acid (ASA) and an angiotensin receptor antagonist. In her examinations it was found that her white blood cell count was 13.7 × 103/μL, hemoglobin level was 14.8 g/dL, mean corpuscular volume was 60 fL, and platele