doi: 10.3389/fonc.2014.00243 Prostate cancer and new insights in angiogenesis

Angiogenesis is considered one of the hallmarks of tumor initiation and pro-gression therefore it is also the widely accepted therapeutic target. It has been shown that angiogenesis blockers prolong patient’s survival for several months (1). In order to progress, cancer cells acquire several distinct morphological alterations increasing their capacity to proliferate and independently sustain growth, and at the same time, inhibit homeostatic, physio-logic signals from the microenvironment they are in, and under the control of which they should have remained. This is the main principle behind a tumor gaining th