doi:10.1100/2012/583751 The cientificWorldJOURNAL Clinical Study Central Precocious Puberty: Treatment with Triptorelin 11.25 mg

Copyright © 2012 Elena Chiocca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Few data are available on quarterly 11.25mg GnRH analog treatment in central precocious puberty (CPP). Aim. To assess the efficacy of triptorelin 11.25mg in children with CPP. Patients. 17 patients (16 females) with CPP (7.9 ± 0.9 years) were treated with triptorelin 11.25mg/90 days.Methods. Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pub-ertal signs were assessed at preinclusion and at inclusion visit, 3 months, 6 months, and 12 months of treatment. Results. At 3, 6, and 12 months, all patients had suppressed LH peak (<3 IU/L after GnRH stimulation), as well as prepubertal oestradiol levels. Mean LH peak values after GnRH test significantly decreased from 25.7±16.5 IU/L at baseline to 0.9±0.5 IU/L at M3 (P < 0.0001); they did not significantly changed at M6 and M12. Conclusions. Triptorelin 11.25mg/90 days efficiently suppressed the pituitary