Research Article MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue

Copyright © 2015 Tung-Yueh Chuang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipidmetabolism.We previously reported that adipose tissue (AT) fromwomenwith polycystic ovary syndrome (PCOS) or controls with insulin resistance (IR) revealed a differentially expressed microRNA (miRNA) profile, including upregulatedmiR-93 in PCOS patients and in non-PCOSwomenwith IR.OverexpressedmiR-93 directly inhibited glucose transporter isoform 4 (GLUT4) expression, thereby influencing glucose metabolism.We have now studied the role of miR-223, which is also abnormally expressed in the AT of IR subjects. Our data indicates that miR-223 is significantly overexpressed in the AT of IRwomen, regardless of whether they had PCOS or not. miR-223 expression in ATwas positively correlated withHOMA-IR. Unlike what is reported in cardiomyocytes, overexpression of miR-223 in human differentiated adipocytes was associated wit