Review Article Efficacy of Telmisartan Plus Amlodipine in Nonresponders to

Copyright © 2013 Steen Neldam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hypertensive patients unable to reach blood pressure (BP) targets with antihypertensive monotherapy may be switched to a combination of two medications with complementary modes of action for improved treatment response. This post hoc analysis pools data from 2812 patients, 1891 of whom were not at goal (diastolic BP [DBP] <90mmHg) with amlodipine 5mg (A5) monotherapy who subsequently switched to telmisartan 40 or 80mg (T80)/A5 single-pill combination (SPC) or amlodipine 10mg (A10) monotherapy, and considers an additional 921 patients, 616 of whom were not at goal with A10 monotherapy who switched to telmisartan/amlodipine SPC. Patients switched to telmisartan/amlodipine SPC achieved significantly greater BP reductions compared with continued monotherapy