Research Article HMGB1 Is Involved in the Protective Effect of the PPAR

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. High mobility group box 1 (HMGB1) is a ubiquitous nuclear DNA-binding protein whose function is dependent on its cellular location. Extracellular HMGB1 is regarded as a delayed mediator of proinflammatory cytokines for initiating and amplifying inflammatory responses, whereas nuclear HMGB1 has been found to prevent cardiac hypertrophy and heart failure. Because fenofibrate, a peroxisome proliferator-activated recepto