EDITORIAL EuroFlow: Resetting leukemia and lymphoma

immunophenotyping. Basis for companion diagnostics and personalized medicine Leukemia (2012) 26, 1899–1907; doi:10.1038/leu.2012.121 Laboratory diagnostics in patients with a hematological malig-nancy has three major applications: establishing the diagnosis, prognostic classification and evaluation of treatment effective-ness.1,2 Immunophenotyping is currently recognized to provide essential information for all three applications.2–9 Expression of individual immunophenotypic markers was initially assessed by microscopic techniques, but since the 90’s multiparameter flow cytometric immunophenotyping has become the technique of choice, as it is the sole technique that fulfills the requirements for high speed, broad applicability at diagnosis and during follow-up, and accurate focusing on the malignant cell population using membrane-bound and intracellular proteins as targets.9–14 Despit