Background: Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchymal phenotype is a common paradigm for both resistance to therapy and tumor recurrence. However, the mesenchymalization of carcinomas has not yet entered clinical practice as a crucial diagnostic paradigm. Methodology/Principal Findings: By integrating in silico and in vitro studies with our epithelial and mesenchymal tumor models, we compare herein crucial molecular pathways of previously described carcinoma-derived mesenchymal tumor cells (A17) with that of both carcinomas and other mesenchymal phenotypes, such as mesenchymal stem cells (MSCs), breast stroma, and various types of sarcomas. We identified three mesenchymal/stromal...
Carcinoma-associated mesenchymal stem cells (CA-MSCs) are critical stromal progenitor cells within t...
<div><p>Introduction</p><p>Metastases remain the primary cause of cancer-related death. The acquisit...
Targeting breast cancer stem cells promises to eliminate the root of metastasis and recurrence and t...
BACKGROUND: Mounting clinical and experimental evidence suggests that the shift of carcinomas towar...
Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchy...
Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchy...
Metaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cancer. It is gen...
Metastasis is the leading cause of cancer-related death, and bone marrow (BM) is a prominent metasta...
Mesenchymal stromal cells (MSCs) are key contributors of the tumour microenvironment and are known t...
[[abstract]]Metaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cance...
Despite major advances in understanding the molecular and genetic basis of cancer, metastasis remain...
To better understand the relationship between tumor-host interactions and the efficacy of chemothera...
Breast cancer is a heterogeneous disease that is characterized by a high grade of cell plasticity ar...
SummaryPrevious studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are...
2011/2012Mesenchymal Stem/Stromal Cells (MSCs) are the precursors of various cell types that compose...
Carcinoma-associated mesenchymal stem cells (CA-MSCs) are critical stromal progenitor cells within t...
<div><p>Introduction</p><p>Metastases remain the primary cause of cancer-related death. The acquisit...
Targeting breast cancer stem cells promises to eliminate the root of metastasis and recurrence and t...
BACKGROUND: Mounting clinical and experimental evidence suggests that the shift of carcinomas towar...
Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchy...
Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchy...
Metaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cancer. It is gen...
Metastasis is the leading cause of cancer-related death, and bone marrow (BM) is a prominent metasta...
Mesenchymal stromal cells (MSCs) are key contributors of the tumour microenvironment and are known t...
[[abstract]]Metaplastic carcinoma of the breast (MCB) is a poorly understood subtype of breast cance...
Despite major advances in understanding the molecular and genetic basis of cancer, metastasis remain...
To better understand the relationship between tumor-host interactions and the efficacy of chemothera...
Breast cancer is a heterogeneous disease that is characterized by a high grade of cell plasticity ar...
SummaryPrevious studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are...
2011/2012Mesenchymal Stem/Stromal Cells (MSCs) are the precursors of various cell types that compose...
Carcinoma-associated mesenchymal stem cells (CA-MSCs) are critical stromal progenitor cells within t...
<div><p>Introduction</p><p>Metastases remain the primary cause of cancer-related death. The acquisit...
Targeting breast cancer stem cells promises to eliminate the root of metastasis and recurrence and t...