Received: 19.01.2014, accepted: 25.03.2014. Cardiovascular safety of antihistamines

Histamine is a mediator, which increases the permeability of capillaries during the early phase of allergic reaction, causes smooth muscle contraction of bronchi and stimulates mucous glands in the nasal cavity. Antihistamines are the basis of symptomatic treatment in the majority of allergic diseases, especially allergic rhinitis, allergic conjunc-tivitis, urticaria and anaphylaxis. The cardiotoxic effects of the two withdrawn drugs, terfenadine and astemizole, were manifested by prolonged QT intervals and triggering torsades de pointes (TdP) caused by blockade of the ‘rapid ’ I Kr potassium channels. These phenomena, however, are not a class effect. This review deals with a new generation of antihistamine drugs in the context of QT interval prolongation risk. Key words: histamine, H1 receptor, antihistamines, QT interval, torsades de pointes. Histamine is a mediator abundantly released by mast cells. It covers a broad spectrum of biological activities executed through the pathways of H1, H2, H3 (present mainly in the nervous tissues), and H4 receptors, as well as through the intracellular Hic receptor [1, 2]. The symp