Add to ORKGIntroduction: Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secreted adipokine angiopoietin-like 4 (ANGPTL4) specifically increases osteoclast-mediated bone resorption. We have investigated expression of ANGPTL4 and its regulatory transcription factor, hypoxia-inducible factor-1 alpha (HIF-1a), in osteoclasts and other cells within rheumatoid synovium. We have also examined whether circulating levels of ANGPTL4 differ in RA patients compared with that in normal controls or patients with osteoarthritis (OA)
<p>(A) HIF-1α expression by osteoclasts in the RA synovium (arrows). Representative image from n = 3...
Methods. Serum levels of VEGF, soluble vascular cell adhesion molecule (sVCAM)-1 and angiopoietin-2 ...
Abstract Background We have previously reported that adiponectin (AD), an adipokine that is secreted...
Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secrete...
BACKGROUND AND OBJECTIVES: In contrast to normal synovial tissue, rheumatoid synovium is hypoxic, an...
Hypoxia and the Hypoxia-Inducible Factor (HIF) transcription factor drive pathological bone 2 loss i...
Our previous studies of gene expression profiling during collagen-induced arthritis (CIA) indicated ...
Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is h...
<p>(A) ANGPTL4 is strongly expressed by osteoclasts (arrows) in the RA synovium. Inset: Representati...
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic c...
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic c...
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride m...
<p>(A) The RA synovium is strongly positive for ANGPTL4, as are adjacent blood vessels and surroundi...
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride m...
OBJECTIVES: Despite the important role of the transcription factor HIF-1alpha in angiogenesis and in...
<p>(A) HIF-1α expression by osteoclasts in the RA synovium (arrows). Representative image from n = 3...
Methods. Serum levels of VEGF, soluble vascular cell adhesion molecule (sVCAM)-1 and angiopoietin-2 ...
Abstract Background We have previously reported that adiponectin (AD), an adipokine that is secreted...
Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secrete...
BACKGROUND AND OBJECTIVES: In contrast to normal synovial tissue, rheumatoid synovium is hypoxic, an...
Hypoxia and the Hypoxia-Inducible Factor (HIF) transcription factor drive pathological bone 2 loss i...
Our previous studies of gene expression profiling during collagen-induced arthritis (CIA) indicated ...
Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is h...
<p>(A) ANGPTL4 is strongly expressed by osteoclasts (arrows) in the RA synovium. Inset: Representati...
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic c...
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic c...
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride m...
<p>(A) The RA synovium is strongly positive for ANGPTL4, as are adjacent blood vessels and surroundi...
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride m...
OBJECTIVES: Despite the important role of the transcription factor HIF-1alpha in angiogenesis and in...
<p>(A) HIF-1α expression by osteoclasts in the RA synovium (arrows). Representative image from n = 3...
Methods. Serum levels of VEGF, soluble vascular cell adhesion molecule (sVCAM)-1 and angiopoietin-2 ...
Abstract Background We have previously reported that adiponectin (AD), an adipokine that is secreted...