Review Article Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage inmice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis.The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF