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We report the association of primary hyperparathyroidism (PHPT) and Klinefelter’s syndrome (KS) in a 22-year-old male complaining of worsening fatigue. PHPT was asymptomatic at the diagnosis, but the patient had worsening hypercalcemia Klinefelter’s syndrome (KS) is the most common genetic Hypogonadism represents one of the most impor-contradictory results as for BMD. f A 22-year-old male was referred to our Endocrine Unit He was tall (180 cm) and not obese (BMI 18 kg/m2) with E Castellano and others PHPT and Klinefelter’s syndrome in a young man ID: 15-0019; April 2015 DOI: 10.1530/EDM-15-0019mineral density (BMD) affects morbidity risk and mortalitytant causes of male osteoporosis; early onset of testosterone deficiency, as observed in KS, is an important risk factor for precocious osteoporosis (2). Signs of osteoporosis are detected in up to 40 % of KS patients. The reduction in bone for worsening of fatigue. There was no family history of endocrine malignancy or endocrinopathy. Personal history was uneventful. Physical examination disclosed small testes (8 ml) and sparse beard growth.cause of human male infertility, with a reported preva-lence of 0.1–0.2 % in the general population. The disease is widely underdiagnosed and the suspicion is usually driven by symptoms of hypogonadism (1). The typical endocrine derangements include decreased secretion of androgens and elevated gonadotropin levels. Low vitamin D and high p levels are frequent findings i contrary, the coexistence o parathyroidism (PHPT) is very herein the second case of this Case presentationfrom fractures in KS patients (3). Longitudinal studies in eunuchoid proportion (arm sp This work is licensed under a Creative Common