Short Communication SEROLOGICAL CHANGES ASSOCIATED WITH C. PARVUM TREATMENT IN NUDE MICE

WHILE investigating the effects of C. parvum administration on tumour growth in mice, we observed a number of serological responses. For example, anti-bodies which react with C. parvum and with the cells of a chemically induced fibrosarcoma were elicited, and there was also a marked increase in the level of certain immunoglobulins (Woodruff, McBride and Dunbar, 1974; James et al., 1976). These effects (as well as the antitumour properties) were observed in both intact mice and mice made T-cell-deficient by adult thymectomy, whole-body irradiation and rescue with isogenei