Research Article The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pharmacologic Relevance.Resveratrol, an antioxidant derived fromgrapes, has been reported tomodulate the inflammatory process. In this study, we investigated the effects of resveratrol and its mechanism of protection on concanavalin-A- (ConA-) induced liver injury in mice.Materials and Methods. Acute autoimmune hepatitis was induced by ConA (20mg/kg) in Balb/C mice; mice were treated with resveratrol (10, 20, and 30mg/kg) daily by oral gavage for fourteen days prior to a single intravenous injection of ConA. Eight hours after injection, histologic grading, proinflammatory cytokine levels, and hedgehog pathway activity were determined. Results.After ConA injection, the cytokines IL-2, IL-6, and TNF