Anxiety and Depression in Patients With Variable Common Immunodeficiency in the Service of Allergy and Clinical

non-modified extract was 90.34 6 75.57 U versus 76.19 6 70.31 U against the allergoid (P 0.16; Mann-Whitney). Linear regression coefficients obtained between immunoglobulin reactivity against both extracts were: r2 0.51 for specific IgE and r2 0.83 for specific IgG. An important decrease in the allergenic activity, measured by inhibition ELISA, was clearly observed. The MS/MS assay revealed the presence of the mayor allergen, and some isoforms, in non-modified and allergoid extracts. Conclusions: Results obtained demonstrate that the glutaraldehyde polymer-ization process induces an important decrease in specific IgE binding to allergoids of P. pratense while there are no significant differences in specific IgG binding. The allergenic composition of the P. pratense allergoid was equivalent to the non-modified pollen extract