aly, including mutations in LIS1, DCX, ARX, RELN,

VLDLR, WDR62, and TUBA1A genes. One may some-times suggest the most likely gene mutation upon MRI findings when some specific features are seen, although image findings overlap among the causative gene mutations. A 1-year-old boy presented with intractable epi-lepsy, developmental delay and microcephalus. Brain MRI revealed lissencephaly with severe dysplasia of the cerebellum and brainstem. Diffusion tensor imaging (DTI) visualized radially aligned structures within the cortex, which is not observed in normal brain after birth (Fig. 1). Combination of severe posterior fossa abnormalities with lissencephaly sug-gested TUBA1A as the most likely responsible gene mutation. Mutation analysis of TUBA1A gen