Allergic reaction in the use of primacaine adrenaline

Articaine hydrochloride and adrenaline injection, also known as primacaine adrenaline, is an aqueous solution of 4 % adrenaline with 1: 100,000 adrena-line [1]. Its advantages include fast diffusion through tissues, low dosage, strong local anesthesia efficacy, rapid onset, long duration, being less toxic than lido-caine and avoiding conduction anesthesia complica-tions, like hematoma, infection and nerve injury. It is suitable for local infiltration anesthesia [2] and works quite well clinically in buccal infiltration anesthesia and conduction anesthesia in surgical procedures of oste-otomy and mucosal incision [3]. The associated side effects of articaine and adrenaline injection are minor and will disappear after the therapy, and they include neuropathy, nervousness, drowsiness, tremors, anxiety