Background: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3) from proinsulin and proglucagon, are associated with type 2 diabetes (T2DM) and coronary artery disease (CAD). The aim of this study is to investigate the association of PCSK1 gene, which encodes PC1/3, with the risk of CAD in Chinese patients with T2DM. Methods: We selected and genotyped 5 haplotype-tagging single nucleotide polymorphisms (SNPs) at PCSK1 gene (across 39873bp locus) in a case-control study of Chinese Han population involving 425 diabetic patients (62.1 % male, mean age 63.2 years) with CAD as positive cases and 258 diabetic patients (44.2 % male, mean age 62.0 years) without CAD as controls. Results: The allele frequencies ...
Background Genome-wide association studies (GWAS) have identified dozens of single nucleotide poly-m...
Genome-wide association studies (GWAS) have identified dozens of single nucleotide polymorphisms (SN...
Most genetic variants identified for type 2 diabetes have been discovered in European populations. W...
Background: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3...
BACKGROUND: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3...
Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3) from proin...
Background. Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular syste...
Background. Glucose-dependent insulinotropic polypeptide (GIP) is closely related to diabetes and ob...
International audienceBackground: Patients with type 1 diabetes are more at risk of coronary artery ...
BACKGROUND: The mechanisms underlying the association between diabetes and coronary artery disease (...
Objective Previous studies have proved that GLP-1 had cardiovascular protective effects by directly ...
[[abstract]]Bcakground: A recent genome-wide association study for type 2 diabetes in Han Chinese id...
Objective: Heredity plays an important role in the predisposition to atherosclerotic coronary artery...
Background: Myocardial infarction (MI) is a serious complication of Coronary Artery Disease (CAD). P...
IMPORTANCE: Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous s...
Background Genome-wide association studies (GWAS) have identified dozens of single nucleotide poly-m...
Genome-wide association studies (GWAS) have identified dozens of single nucleotide polymorphisms (SN...
Most genetic variants identified for type 2 diabetes have been discovered in European populations. W...
Background: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3...
BACKGROUND: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3...
Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3) from proin...
Background. Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular syste...
Background. Glucose-dependent insulinotropic polypeptide (GIP) is closely related to diabetes and ob...
International audienceBackground: Patients with type 1 diabetes are more at risk of coronary artery ...
BACKGROUND: The mechanisms underlying the association between diabetes and coronary artery disease (...
Objective Previous studies have proved that GLP-1 had cardiovascular protective effects by directly ...
[[abstract]]Bcakground: A recent genome-wide association study for type 2 diabetes in Han Chinese id...
Objective: Heredity plays an important role in the predisposition to atherosclerotic coronary artery...
Background: Myocardial infarction (MI) is a serious complication of Coronary Artery Disease (CAD). P...
IMPORTANCE: Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous s...
Background Genome-wide association studies (GWAS) have identified dozens of single nucleotide poly-m...
Genome-wide association studies (GWAS) have identified dozens of single nucleotide polymorphisms (SN...
Most genetic variants identified for type 2 diabetes have been discovered in European populations. W...