RESEARCH ARTICLE

cancer cell metastasis: mo arm vascular tissues of the body in response to certain external anti-cytokine approaches including, cytokine neutralization Dhanjal et al. BMC Cancer 2014, 14:775 http://www.biomedcentral.com/1471-2407/14/77517-kDa soluble component of TNF-α is released into theTechnology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305 8562, Japan Full list of author information is available at the end of the articlestimuli. It involves various chemical mediators called cyto-kines that help in the healing of infected tissues. Even though it is a protective response within the body, it may sometimes result in chronic and life threatening effects like rheumatoid arthritis, hay fever, neurodegenerative diseases and cancer [1]. Regulation of cytokines is by soluble receptors or activation of anti-inflammatory pathways using monoclonal antibodies are in practice [2]. Tumor necrosis factor alpha (TNF-α), a major immuno-modulator and pro-inflammatory cytokine, plays a crucial role in various immunological disorders and inflammations in skin. TNF-α receptors are found in almost all cell types and are known to be involved in several physiological processes. It also leads to multiple inflammatory reactions by inducing the production of secondary cytokines [3]. TNF-α is synthesized as a 223 amino acid long membrane-anchored precursor protein (pro-TNF-α) of 26-kDa. Th