Add to ORKGAge at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large-scale meta-analysis of genome-wide association studies using more than 15,000 Japanese female samples. Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.4961027 and an effect size of 0.089 (year). We also evaluated 33 SNPs that were previously reported to be associated with AAM in women of European ancestry. Among them, two SNPs rs4452860 and rs7028916 in TMEM38B indicated significant association with AAM in the same directions as reported in previous studies (P = 0.0013 with an effect size o...
Current knowledge of the genetic architecture of key reproductive events across the female life cour...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
<p>Genotyping result of 15,495 Japanese subjects were anlayzed in this study. Imputed SNPs with R2 o...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Context: Age at menarche (AAM) is an important trait both biologically and socially, a clearly defin...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Objective The aim of this study was to identify polymorphisms and gene-gene interactions that are si...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Current knowledge of the genetic architecture of key reproductive events across the female life cour...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
<p>Genotyping result of 15,495 Japanese subjects were anlayzed in this study. Imputed SNPs with R2 o...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identi...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Context: Age at menarche (AAM) is an important trait both biologically and socially, a clearly defin...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Objective The aim of this study was to identify polymorphisms and gene-gene interactions that are si...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
Current knowledge of the genetic architecture of key reproductive events across the female life cour...
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association stu...
<p>Genotyping result of 15,495 Japanese subjects were anlayzed in this study. Imputed SNPs with R2 o...