Correlation Between High-Density Lipoprotein and Monocyte Subsets in Patients with Stable Coronary Heart Disease

Source of support: Departmental sources Background: High-density lipoprotein (HDL) consists of heterogeneous particles with a variety of structures and functions. Its role in atherosclerosis has been gradually recognized. Studies have shown dysfunction of small HDL in pa-tients with coronary artery disease (CAD). Monocytes play an important role in atherosclerosis, which can be divided into 3 subgroups based on the expression of surface markers CD14 and CD16. This study aimed to in-vestigate the association between HDL and monocyte subsets in CAD patients. Material/Methods: A total of 90 patients with stable CAD were selected in this study. Monocytes were divided into classical mono-cytes (CM, CD14++CD16-), intermediate monocytes (IM, CD14++CD16+), and non-classical monocytes (NCM, CD14+CD16++). HDL components in serum were determined by high-resolution polyacrylamide gel electro-phoresis (detected by Quantimetrix HDL Lipoprint system, referring to HDL subfractions analysis: A new labo-ratory diagnostic assay for patients with cardiovascular diseases and dyslipoproteinemia). Results: Serum level of small HDL was positively correlated with circulating proinflammatory NCM (r=0.30; p=0.004), negatively correlated with CM, and not correlated with IM. We also found that disease severity was not asso-ciated with diabetes mellitus, glycosylated hemoglobin, hypertension, smoking history, or statin dosage. Conclusions: Our study confirmed that small HDL level is associated with an increase in NCM and a decrease in CM, sug