Clinical and Cognitive Phenotype of Mild Cognitive Impairment Evolving to

Mild cognitive impairment Objective: The aim of this study was to determine which characteristics could better distin-guish dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) at the mild cognitive impairment (MCI) stage, with particular emphasis on visual space and object perception abil-ities. Methods: Fifty-three patients with mild cognitive deficits that were eventually diagnosed with probable DLB (MCI-DLB: n = 25) and AD (MCI-AD: n = 28) at a 3-year follow-up were retrospectively studied. At the first visit, the patients underwent cognitive assessment includ-ing the Qualitative Scoring Mini Mental State Examination Pentagon Test and the Visual Ob-ject and Space Perception Battery. The Neuropsychiatric Inventory Questionnaire, Unified Parkinson’s Disease Rating Scale (UPDRS) and questionnaires for cognitive fluctuations and sleep disorders were also administered. Results: The best clinical predictor of DLB was the presence of soft extrapyramidal signs (mean UPDRS score: 4.04 ± 5.9) detected in 72 % of pa-tients, followed by REM sleep behavior disorder (60%) and fluctuations (60%). Wrong perfor-mances in the pentagon’s number of angles were obtained in 44 % of DLB and 3.7 % of A