Add to ORKG† These authors contributed equally to this work. ‡ Both authors jointly directed this work. Abstract: One challenge in colorectal cancer (CRC) is identifying novel biomarkers to be introduced in screening programs. The present study investigated the promoter methylation status of the SEPT9 gene in peripheral blood samples of subjects ’ positive fecal occult blood test (FOBT). In order to add new insights, we investigated the association between SEPT9 promoter methylation and micronuclei frequency, and polymorphisms in the folate-related pathway genes. SEPT9 promoter methylation, micronuclei frequency, and genotypes were evaluated on 74 individuals ’ FOB
Research on DNA methylation offers great potential for the identification of biomarkers that can be ...
The detection of Colorectal Cancer (CRC), at early stages, is one of the proven strategies resulting...
Fulltext embargoed for: 12 months post date of publicationChanges in the methylation levels of DNA f...
One challenge in colorectal cancer (CRC) is identifying novel biomarkers to be introduced in screeni...
Background: Determination of methylated Septin 9 (mSEPT9) in plasma has been shown to be a sensitive...
Microarray analysis of promoter hypermethylation provides insight into the role and extent of DNA me...
A panel of genes methylated with high frequency in colorectal cancer very low methylation in non-neo...
Background: The septin 9 gene (SEPT9) codes for a GTP-binding protein associated with filamentous st...
Background: The development of colorectal cancer (CRC) is accompanied by extensive epigenetic change...
Background: DNA methylation is commonly linked with the silencing of the gene expression for many tu...
We evaluated the promoter methylation levels of the APC, MGMT, hMLH1, RASSF1A and CDKN2A genes in 10...
OBJECTIVES: While promoter hypermethylation is a common molecular alteration of human colorectal can...
Colorectal cancer (CRC) is characterized by the accumulation of genetic and epigenetic alterations a...
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the diseas...
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing i...
Research on DNA methylation offers great potential for the identification of biomarkers that can be ...
The detection of Colorectal Cancer (CRC), at early stages, is one of the proven strategies resulting...
Fulltext embargoed for: 12 months post date of publicationChanges in the methylation levels of DNA f...
One challenge in colorectal cancer (CRC) is identifying novel biomarkers to be introduced in screeni...
Background: Determination of methylated Septin 9 (mSEPT9) in plasma has been shown to be a sensitive...
Microarray analysis of promoter hypermethylation provides insight into the role and extent of DNA me...
A panel of genes methylated with high frequency in colorectal cancer very low methylation in non-neo...
Background: The septin 9 gene (SEPT9) codes for a GTP-binding protein associated with filamentous st...
Background: The development of colorectal cancer (CRC) is accompanied by extensive epigenetic change...
Background: DNA methylation is commonly linked with the silencing of the gene expression for many tu...
We evaluated the promoter methylation levels of the APC, MGMT, hMLH1, RASSF1A and CDKN2A genes in 10...
OBJECTIVES: While promoter hypermethylation is a common molecular alteration of human colorectal can...
Colorectal cancer (CRC) is characterized by the accumulation of genetic and epigenetic alterations a...
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the diseas...
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing i...
Research on DNA methylation offers great potential for the identification of biomarkers that can be ...
The detection of Colorectal Cancer (CRC), at early stages, is one of the proven strategies resulting...
Fulltext embargoed for: 12 months post date of publicationChanges in the methylation levels of DNA f...