Abstract The putative chromatin remodeling enzyme Plk1-interacting checkpoint helicase (PICH) was discovered as an interaction partner and substrate of the mitotic kinase Plk1. During mitosis PICH associates with centromeres and kinet-ochores and, most interestingly, constitutes a robust marker for ultrafine DNA bridges (UFBs) that connect separating chromatids in anaphase cells. The precise roles of PICH remain to be clarified. Here, we have used antibody micro-injection and siRNA-rescue experiments to study PICH function and localization during M phase progression, with particular emphasis on the role of the predicted ATPase domain and the regulation of PICH localization by Plk1. We show that interference with PICH function results in chr...
Mammalian polo-like kinase 1 (Plk1) is structurally related to the polo gene product of Drosophila m...
PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numer...
<div><p>Centromeres are specialized chromosome domains that control chromosome segregation during mi...
The putative chromatin remodeling enzyme Plk1-interacting checkpoint helicase (PICH) was discovered ...
The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFB...
Abstract PICH (Plk1-interacting checkpoint helicase) was recently identified as an essential compone...
SummaryWe identify PICH (Plk1-interacting checkpoint “helicase”), a member of the SNF2 ATPase family...
The DNA-dependent adenosine triphosphatase (ATPase) Plk1-interacting checkpoint helicase (PICH) has ...
Proper chromosome segregation is essential for faithful cell division and if not maintained results ...
The DNA-dependent adenosine triphosphatase (ATPase) Plk1-interacting checkpoint helicase (PICH) has ...
The microrchidia (MORC) family of proteins are widely conserved eukaryotic and prokaryotic organisms...
Resumen del trabajo presentado al 1st MeioNet Meeting, celebrado en Poblet, Tarragona (España) del 1...
In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to “threads” that remai...
DNA replication is a complex and highly regulated cellular process that ensures faithful duplication...
Summary: PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges an...
Mammalian polo-like kinase 1 (Plk1) is structurally related to the polo gene product of Drosophila m...
PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numer...
<div><p>Centromeres are specialized chromosome domains that control chromosome segregation during mi...
The putative chromatin remodeling enzyme Plk1-interacting checkpoint helicase (PICH) was discovered ...
The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFB...
Abstract PICH (Plk1-interacting checkpoint helicase) was recently identified as an essential compone...
SummaryWe identify PICH (Plk1-interacting checkpoint “helicase”), a member of the SNF2 ATPase family...
The DNA-dependent adenosine triphosphatase (ATPase) Plk1-interacting checkpoint helicase (PICH) has ...
Proper chromosome segregation is essential for faithful cell division and if not maintained results ...
The DNA-dependent adenosine triphosphatase (ATPase) Plk1-interacting checkpoint helicase (PICH) has ...
The microrchidia (MORC) family of proteins are widely conserved eukaryotic and prokaryotic organisms...
Resumen del trabajo presentado al 1st MeioNet Meeting, celebrado en Poblet, Tarragona (España) del 1...
In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to “threads” that remai...
DNA replication is a complex and highly regulated cellular process that ensures faithful duplication...
Summary: PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges an...
Mammalian polo-like kinase 1 (Plk1) is structurally related to the polo gene product of Drosophila m...
PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numer...
<div><p>Centromeres are specialized chromosome domains that control chromosome segregation during mi...