sORFs.org: a repository of small ORFs identified by ribosome profiling

With the advent of ribosome profiling, a next gen-eration sequencing technique providing a “snap-shot ” of translated mRNA in a cell, many short open reading frames (sORFs) with ribosomal activity were identified. Follow-up studies revealed the ex-istence of functional peptides, so-called micropep-tides, translated from these ‘sORFs’, indicating a new class of bio-active peptides. Over the last few years, several micropeptides exhibiting important cellular functions were discovered. However, ribosome oc-cupancy does not necessarily imply an actual func-tion of the translated peptide, leading to the de-velopment of various tools assessing the coding potential of sORFs. Here, we introduce sORFs.or