Add to ORKGBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA motifs within the microsatellite. Objectives: Here we sought to examine the polymorphic spectrum of a GGAA-microsatellite within the NR0B1 promoter (a critical EWS/FLI target) in primary Ewing sarcoma tumors, and characterize how this polymorphism influences gene expression and clinical outcomes. Results: A complex, bimodal pattern of EWS/FLI-mediated ...
Ewing sarcoma is the second most common form of pediatric bone cancer and is characterized by chromo...
International audienceEwing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusi...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...
BackgroundThe genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood....
<div><p>Background</p><p>The genetics involved in Ewing sarcoma susceptibility and prognosis are poo...
BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understoo...
pre-printBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly ...
<div><p>Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EW...
Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI ch...
Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. C...
<p>(<b>A</b>) EFS was compared in 112 patients from AEWS0031 based on the presence of absence of at ...
International audienceDeciphering the ways in which somatic mutations and germline susceptibility va...
<p>(<b>A</b>) Principal components analysis comparing unique microsatellite haplotypes in tumor samp...
Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusion. We performed a gen...
Ewing sarcoma is the second most common form of pediatric bone cancer and is characterized by chromo...
International audienceEwing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusi...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...
BackgroundThe genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood....
<div><p>Background</p><p>The genetics involved in Ewing sarcoma susceptibility and prognosis are poo...
BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understoo...
pre-printBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly ...
<div><p>Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EW...
Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI ch...
Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. C...
<p>(<b>A</b>) EFS was compared in 112 patients from AEWS0031 based on the presence of absence of at ...
International audienceDeciphering the ways in which somatic mutations and germline susceptibility va...
<p>(<b>A</b>) Principal components analysis comparing unique microsatellite haplotypes in tumor samp...
Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusion. We performed a gen...
Ewing sarcoma is the second most common form of pediatric bone cancer and is characterized by chromo...
International audienceEwing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusi...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...