the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease

Copyright © 2013 Zhi-Gang Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Traditional Chinese Medicine (TCM) is a complete medical system that has been practiced for more than 3000 years. Prescription number 1 (PN-1) consists of several Chinese medicines and is designed according to TCM theories to treat patients with neuropsychiatric disorders. The evidence of clinical practice suggests the benefit effects of PN-1 on cognitive deficits of dementia patients. We try to prove and explain this by using contemporary methodology and transgenic animal models of Alzheimer’s disease (AD).The behavioral studies were developed to evaluate thememory of transgenic animals after intragastric administration of PN-1 for 3 months. Amyloid beta-protein (