Add to ORKGCopyright © 2010 Kathryn P. Burdon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. Methods. Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS). European American diabetic (n = 828) and nondiabetic (n = 170) siblings were genotyped for SNPs in ...
Coronary heart disease (CHD) affects 17 million people in the United States and accounts for over a ...
textabstractOBJECTIVE-: Genetic studies might provide new insights into the biological mechanisms un...
To access publisher's full text version of this article, please click on the hyperlink in Additional...
Objectives: To investigate the arachionate 5-lipoxygenase-activating protein (ALOX5AP) gene as a pot...
UnrestrictedThis study provides a review of the literature on coronary artery disease (CAD) focusing...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
The major underlying cause of CHD is atherosclerosis, and oxidised LDL is known to play an important...
The 5-lipoxygenase pathway (5-LOX) has been implicated in the development of cardiovascular disease ...
Includes bibliographical references (leaves 26-31).Coronary artery disease (CAD) is a multifactorial...
The 12/15-lipoxygenase plays a janus-role in inflammation with pro-inflammatory and anti-inflammator...
a b s t r a c t Mammalian lipoxygenases play a role in normal cell development and differentiation b...
The aim of this study was to explore the role of variants of the gene encoding arachidonate 5-lipoxy...
Atherosclerosis, a major cause of disability and death, is a multifactorial disease with a strong he...
Background: The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. W...
Background: Leukotrienes are inflammatory mediators derived from arachidonic acid via the 5-lipoxy...
Coronary heart disease (CHD) affects 17 million people in the United States and accounts for over a ...
textabstractOBJECTIVE-: Genetic studies might provide new insights into the biological mechanisms un...
To access publisher's full text version of this article, please click on the hyperlink in Additional...
Objectives: To investigate the arachionate 5-lipoxygenase-activating protein (ALOX5AP) gene as a pot...
UnrestrictedThis study provides a review of the literature on coronary artery disease (CAD) focusing...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
The major underlying cause of CHD is atherosclerosis, and oxidised LDL is known to play an important...
The 5-lipoxygenase pathway (5-LOX) has been implicated in the development of cardiovascular disease ...
Includes bibliographical references (leaves 26-31).Coronary artery disease (CAD) is a multifactorial...
The 12/15-lipoxygenase plays a janus-role in inflammation with pro-inflammatory and anti-inflammator...
a b s t r a c t Mammalian lipoxygenases play a role in normal cell development and differentiation b...
The aim of this study was to explore the role of variants of the gene encoding arachidonate 5-lipoxy...
Atherosclerosis, a major cause of disability and death, is a multifactorial disease with a strong he...
Background: The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. W...
Background: Leukotrienes are inflammatory mediators derived from arachidonic acid via the 5-lipoxy...
Coronary heart disease (CHD) affects 17 million people in the United States and accounts for over a ...
textabstractOBJECTIVE-: Genetic studies might provide new insights into the biological mechanisms un...
To access publisher's full text version of this article, please click on the hyperlink in Additional...