Add to ORKGVarious methods have been developed to assess the effects of chemical substances on reproduction. In some instances, the tests have been developed to define the effects of treatment on specific segments of the reproductive cycle. In other cases, studies are conducted to determine the cumulative effects of treatment during one or more generations. The structure, advantages, and disadvantages of three types of conven-tional reproduction studies are reviewed. An outline of the procedural sequences, observations, and record evaluation required in the three-period reproduction study, the three-generation reproduction study, and the multigeneration reproduction study are presented
From this literature survey it appeared that there is a considerable lack of information with respec...
The assessment of transgenerational effects should be incorporated in standard chronic toxicity prot...
The arenas of reproductive and developmental toxicology are multifaceted areas of significant import...
Effective and efficient assessment of the potential health effects from environmental chemicals requ...
A regulatory body such as the Environmental Protection Agency has responsibility to determine safe e...
Reviews and studies on individual compounds were analyzed as to the suitability of different study d...
A method to evaluate developmental and reproductive toxicity for a wide variety of chemicals has bee...
The Workshop on One- vs Two-Generation Reproductive Effects Studies was held on October 21-22, 1987....
Three areas of reproductive toxicology have been investigated in this thesis: the development of in ...
SUMMARY A recent review ofthe literature identified several common methodological weaknesses in stud...
Reproductive function has been shown to be sensitive to changes in the physical, psychosocial and ch...
The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxic...
Large scale toxicological testing programmes which are currently ongoing such as the new European ch...
The etiology of male infertilities is largely undetermined, and our knowledge of exogenous factors a...
The process of toxicity testing of environmental chemicals is ruled by a framework of guidelines (OE...
From this literature survey it appeared that there is a considerable lack of information with respec...
The assessment of transgenerational effects should be incorporated in standard chronic toxicity prot...
The arenas of reproductive and developmental toxicology are multifaceted areas of significant import...
Effective and efficient assessment of the potential health effects from environmental chemicals requ...
A regulatory body such as the Environmental Protection Agency has responsibility to determine safe e...
Reviews and studies on individual compounds were analyzed as to the suitability of different study d...
A method to evaluate developmental and reproductive toxicity for a wide variety of chemicals has bee...
The Workshop on One- vs Two-Generation Reproductive Effects Studies was held on October 21-22, 1987....
Three areas of reproductive toxicology have been investigated in this thesis: the development of in ...
SUMMARY A recent review ofthe literature identified several common methodological weaknesses in stud...
Reproductive function has been shown to be sensitive to changes in the physical, psychosocial and ch...
The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxic...
Large scale toxicological testing programmes which are currently ongoing such as the new European ch...
The etiology of male infertilities is largely undetermined, and our knowledge of exogenous factors a...
The process of toxicity testing of environmental chemicals is ruled by a framework of guidelines (OE...
From this literature survey it appeared that there is a considerable lack of information with respec...
The assessment of transgenerational effects should be incorporated in standard chronic toxicity prot...
The arenas of reproductive and developmental toxicology are multifaceted areas of significant import...