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MicroRNAs (miRs) are short endogenously expressed RNAs that regulate gene expres-sion post-transcriptionally. it is known, that both messenger RNA (mRNA) degradation and suppression of mRNA translation can medi-ate reduced protein levels following miR tar-geting of an mRNA. however, the relative contributions of these two mechanisms have remained elusive. According to a previous genome-wide study in mammals employing RNA-sequencing to measure miR effects on mRNA translation and stability, 84–89 percent of miR-induced suppression of gene expres-sion was found to be mediated by degradation of target mRNAs. drs Ola Larsson and Robert Nadon re-analyzed this data set and applie