CeLL CyCLe news & views

enhancer of zeste homolog 2 (eZH2) has been found to be overexpressed in ovarian and other cancers and plays critical roles in cell proliferation, angiogenesis, and inhibition of apoptosis.1,2 Among its many functions, it tri-methylates lysine residue at the 27 position of histone H3 associated with the target gene.3 eZH2 is widely considered an important tar-get for cancer therapy. several approaches to block eZH2, including inhibitors (e.g., GsK126, GsK343, ei1) and siRnA incorporated into nanoparticles, are being examined.2,4-6 it is becoming increasingly clear that 2D in vitro assays may not fully simulate the com-plex tumor microenvironment, likely due t