TetR family transcriptional regulators (TFRs) are found in most bacteria and archea. Most of the family members that have been investigated to date are repressors of their target genes, and the majority of these, like the well-characterized protein TetR, regulate genes that encode transmembrane efflux pumps. In many cases repression by TFR proteins is reversed through the direct binding of a small-molecule ligand. The number of TFRs in the public database has grown rapidly as a result of genome sequencing and there are now thousands of family members; however virtually nothing is known about the biology and biochemistry they regulate. Generally applicable methods for predicting their regulatory targets would assist efforts to characterize t...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Several widely used methods for predicting functional associations between proteins are based on the...
TetR family transcriptional regulators (TFRs) are found in most bacteria and archea. Most of the fam...
<div><p><u>T</u>etR <u>f</u>amily transcriptional <u>r</u>egulators (TFRs) are found in most bacteri...
We have developed a general profile for the proteins of the TetR family of repressors. The stretch t...
The TetR family of microbial transcription factors directly control the expression of a diverse rang...
The TetR family of microbial transcription factors directly control the expression of a diverse rang...
Antibiotic resistance is a worsening threat to human health. Increasing our understanding of the mec...
Comparative genomics approaches are broadly used for analysis of transcriptional regulation in bacte...
Transcription factors (TFs) of bacterial helix–turn–helix superfamilies exhibit different effector-b...
DNA-binding Transcription Factors (TFs) play a central role in regulation of gene expression in prok...
Transcription factors (TFs) control gene expression by direct or indirect activation or repression o...
The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues...
Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to c...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Several widely used methods for predicting functional associations between proteins are based on the...
TetR family transcriptional regulators (TFRs) are found in most bacteria and archea. Most of the fam...
<div><p><u>T</u>etR <u>f</u>amily transcriptional <u>r</u>egulators (TFRs) are found in most bacteri...
We have developed a general profile for the proteins of the TetR family of repressors. The stretch t...
The TetR family of microbial transcription factors directly control the expression of a diverse rang...
The TetR family of microbial transcription factors directly control the expression of a diverse rang...
Antibiotic resistance is a worsening threat to human health. Increasing our understanding of the mec...
Comparative genomics approaches are broadly used for analysis of transcriptional regulation in bacte...
Transcription factors (TFs) of bacterial helix–turn–helix superfamilies exhibit different effector-b...
DNA-binding Transcription Factors (TFs) play a central role in regulation of gene expression in prok...
Transcription factors (TFs) control gene expression by direct or indirect activation or repression o...
The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues...
Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to c...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory net...
Several widely used methods for predicting functional associations between proteins are based on the...