Research Article Inhibition ofHelicobacter pylori CagA-Induced Pathogenesis by

Copyright © 2013 Chun-Jung Lin et al.is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. e bacterial pathogenHelicobacter pylori (Hp) is the leading risk factor for the development of gastric cancer. Hp virulence factor, cytotoxin-associated gene A (CagA) interacted with cholesterol-enrichedmicrodomains and leads to induction of in�ammation in gastric epithelial cells (AGS). In this study, we identi�ed a triterpenoid methylantcinate B (MAB) from the medicinal mushroom Antrodia camphorata which inhibited the translocation and phosphorylation of CagA and caused a reduction in hummingbird phenotype in HP-infected AGS cells. Additionally, MAB suppressed the Hp-induced in�ammatory response by attenuation of NF