STUDY PROTOCOL Open Access Isolated hepatic perfusion e

Full list of author information is available at the end of the articleBackground Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the pri-mary tumor, patients with uveal melanoma have a high risk of developing metastatic disease. In the Collaborative Ocular Melanoma Study (COMS), the cumulative five and 10-year rates were 25 % and 34 % respectively [1]. Moreover, late metastases are frequent, with approxi-mately 50 % of the patients ultimately developing metasta-ses [2]. The liver is the most common site for metastases and about 50 % of the patients with advanced disease will have isolated liver metastases. These metastases are gener-ally refractory to systemic chemotherapy and the median survival for patients with liver metastases is about six months. Regardless of treatment, the mortality rate is approximately 90 % at two years with only about 1 % of patients surviving more than five years [1]