Article type: Original Article

Background: Epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. Up to now, several diagnostic approaches have been processed to determine the epileptic focus. Objectives: The aim of this study was to discover whether proton-MR-spectroscopic im-aging (MRSI) aids in the diagnosis of temporal lobe epilepsy in conjunction with classi-cal electroencephalography (EEG) findings. Patients and Methods: Totally, 70 mesial temporal zones consisting of 39 right hippo-campi and 31 left hippocampi of 46 patients (25 male, 21 female) were analyzed by proton MRSI. All patients underwent a clinical neurologic examination, scalp EEG recording and prolonged video EEG monitoring. Partial seizures on the right, left or both sides were recorded in all patients. All patients were under medical treatment and none of the pa-tients underwent amygdalohippocampectomy and similar surgical procedures. Results: The normal average lactate (Lac), phosphocreatine, N-acetyl aspartate (NAA), creatine (Cr), choline (Cho), myo-inositol, glutamate and glutamine (Glx) peaks and N-acetyl aspartate/Cr, NAA / Cho + Cr, Cho/Cr ratios were measured from the healthy oppo