Clinical Study A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes

Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Among atypical antipsychotics, none has been linked to torsade de pointes. In the present study, the electrocardio-graphic changes induced by olanzapine have been compared with risperidone. Method and Materials. 268 patients were entered into an open study for random assignment to olanzapine or risperidone. ECGwas taken at baseline and at the end of the treatment. The parameters that had been assessed included Q-T interval (corrected = Q-Tc) and other related parameters. Correction of the observed Q-T interval was done according to Frederica’s formula (QTcF). Results. While 14.86 % and 25 % of the cases in th