Objective: ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux protein implicated in the absorption and the distribution of various compounds, including tacrolimus and cyclosporine A. In vivo studies suggest an association between the ABCB1 1199G.A single nucleotide polymorphism (SNP) and tacrolimus intracellular accumulation. The aim of the present experimental study was to clarify in vitro the impact of the coding ABCB1 1199G.A SNP on ABCB1 transport activity towards both immunosuppressive drugs. Method: Two recombinant cell lines, i.e. Human Embryonic Kidney (HEK293) and Human Myelogenous Leukemia (K562) cells, overexpressing ABCB1 carrying either the wild-type allele (1199G) or its mutated co...
AIM: ABCB1 (or P-glycoprotein) is implicated in the multidrug-resistance phenotype, including the re...
International audienceBecause of a narrow therapeutic index and a wide inter- and intra-patient vari...
The calcineurin inhibitor cyclosporine is removed from lymphocytes by the drug efflux transporter P-...
ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux pro...
OBJECTIVE: ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an...
1199G>A SNP on ABCB1 transport activity towards both immunosuppressive drugs. Human Embryonic Kidne...
AIMS: This prospective study investigated the effect of genetic polymorphisms in a biotransformation...
One of the many obstacles to effective drug treatment is the efflux transporter P-glycoprotein (P-gp...
OBJECTIVE: The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABC...
OBJECTIVE: Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation to avoid g...
Background and Objective: Tacrolimus is an immunosuppressive drug used for the prevention of the all...
OBJECTIVE: Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation to avoid g...
International audienceMembrane transporters play an essential role in the pharmacokinetics of drugs ...
Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range an...
Direct oral anticoagulants (DOAC) are substrates for the ABCB1 transporter (also called P-glycoprote...
AIM: ABCB1 (or P-glycoprotein) is implicated in the multidrug-resistance phenotype, including the re...
International audienceBecause of a narrow therapeutic index and a wide inter- and intra-patient vari...
The calcineurin inhibitor cyclosporine is removed from lymphocytes by the drug efflux transporter P-...
ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux pro...
OBJECTIVE: ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an...
1199G>A SNP on ABCB1 transport activity towards both immunosuppressive drugs. Human Embryonic Kidne...
AIMS: This prospective study investigated the effect of genetic polymorphisms in a biotransformation...
One of the many obstacles to effective drug treatment is the efflux transporter P-glycoprotein (P-gp...
OBJECTIVE: The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABC...
OBJECTIVE: Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation to avoid g...
Background and Objective: Tacrolimus is an immunosuppressive drug used for the prevention of the all...
OBJECTIVE: Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation to avoid g...
International audienceMembrane transporters play an essential role in the pharmacokinetics of drugs ...
Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range an...
Direct oral anticoagulants (DOAC) are substrates for the ABCB1 transporter (also called P-glycoprote...
AIM: ABCB1 (or P-glycoprotein) is implicated in the multidrug-resistance phenotype, including the re...
International audienceBecause of a narrow therapeutic index and a wide inter- and intra-patient vari...
The calcineurin inhibitor cyclosporine is removed from lymphocytes by the drug efflux transporter P-...