Add to ORKGRecombinant interferon-alpha (IFN-α) is an approved therapy for chronic hepatitis B (CHB), but the molecular basis of treatment response remains to be determined. The woodchuck model of chronic hepatitis B virus (HBV) infection displays many characteristics of human dis-ease and has been extensively used to evaluate antiviral therapeutics. In this study, wood-chucks with chronic woodchuck hepatitis virus (WHV) infection were treated with recombinant woodchuck IFN-α (wIFN-α) or placebo (n = 12/group) for 15 weeks. Treatment with wIFN-α strongly reduced viral markers in the serum and liver in a subset of animals, with viral reboun
AbstractInterferon-alpha (IFN-α) is a potent suppressor of hepatitis B virus (HBV) replication in th...
Woodchucks infected with woodchuck hepatitis virus (WHV) represent a highly valuable model of human ...
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induct...
<div><p>Recombinant interferon-alpha (IFN-α) is an approved therapy for chronic hepatitis B (CHB), b...
Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis burden, wi...
AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense...
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induct...
Chronic hepatitis B virus (HBV) infection remains a substantial public health burden worldwide. Alph...
Chronic hepatitis B (CHB) results from the inability of the host's immune system to control viral re...
Copyright © 2004 Elsevier Inc. All rights reserved.Interferon-alpha (IFN-α) is a potent suppressor o...
and activators of transcription) pathway participates in the regulation of APOBEC3G (Apolipoprotein ...
Interferon-alpha (IFN-alpha) is a key element in the defense against viral infection because, in add...
<div><p>Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T...
Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell re...
Hepatitis B virus (HBV) is a major pathogen that induces chronic hepatitis in approximately 400 mill...
AbstractInterferon-alpha (IFN-α) is a potent suppressor of hepatitis B virus (HBV) replication in th...
Woodchucks infected with woodchuck hepatitis virus (WHV) represent a highly valuable model of human ...
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induct...
<div><p>Recombinant interferon-alpha (IFN-α) is an approved therapy for chronic hepatitis B (CHB), b...
Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis burden, wi...
AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense...
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induct...
Chronic hepatitis B virus (HBV) infection remains a substantial public health burden worldwide. Alph...
Chronic hepatitis B (CHB) results from the inability of the host's immune system to control viral re...
Copyright © 2004 Elsevier Inc. All rights reserved.Interferon-alpha (IFN-α) is a potent suppressor o...
and activators of transcription) pathway participates in the regulation of APOBEC3G (Apolipoprotein ...
Interferon-alpha (IFN-alpha) is a key element in the defense against viral infection because, in add...
<div><p>Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T...
Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell re...
Hepatitis B virus (HBV) is a major pathogen that induces chronic hepatitis in approximately 400 mill...
AbstractInterferon-alpha (IFN-α) is a potent suppressor of hepatitis B virus (HBV) replication in th...
Woodchucks infected with woodchuck hepatitis virus (WHV) represent a highly valuable model of human ...
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induct...